Bob Sanders will need elbow surgery, will be out for the year
Sanders almost played full seasons in 2005 and 2007, and was an All-Pro in both of those seasons. The Colts are used to playing without him, but he's always hard to replace. No word yet on how long he'll be out.
UPDATE: According to ESPN's Adam Schefter, he's out for the year. That makes 49 missed games in 6 seasons. That's more missed games than games played.