You knew this one was coming, because it's the greatest shot in NCAA Tourney history. This overtime 1992 shot got Duke into the Final Four for the fifth consecutive year, where they repeated as National Champions.
I know Laettner was sort of a disappointment as a pro, but there's no denying he was one of the best college players ever. During this game he was literally perfect. Laettner finished with 31 points on 10-for-10 shooting from both the field (including one 3-pointer) and the foul line.